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THE EVOLUTION OF WOUND BED PREPARATION Unique formulation promoting a rapid wound healing process thanks to Hyaluronic Acid, assisted by the ancillary action of Collagenase.

by the ancillary action of Collagenase.

Boost healing since the beginning.

Ancillary action of Collagenase on necrotic tissue in wound bed preparation(2).

Very smooth and simple to apply(1,3).

3) .

Hyaluronic Acid Sodium Salt 0.2% Collagenase from Vibrio alginolyticus Ointment | 30 g Tube for topical use

Vascular Ulcer Case: RESULTS(4)

Class III Medical Device


No need to protect peri-wound skin(2).

Less pain experienced by the patients(3).


Local management of chronic ulcers (i.e. pressure sores, vascular ulcers of the legs, diabetic ulcers).

In particular, it is intended to provide an optimal moist environment and wound bed preparation that supports the natural healing process(1).

REFERENCES: 1. HYALO4 CARE START, instruction for use; 2. Di Pasquale R, Vaccaro S, Caputo M, et al. Collagenase-assisted wound bed preparation: An in vitro comparison between Vibrio alginolyticus and Clostridium histolyticum collagenases on substrate specificity. Int Wound J. 2019;1–11; 3. Onesti MG, Fioramonti P, Fino P, Sorvillo V, Carella S, Scuderi N. Effect of enzymatic debridement with two different collagenases versus mechanical debridement on chronic hard-to- heal wounds. Int Wound J. 2016;13(6):1111-5; 4. De Francesco F, De Francesco M and Riccio M. Hyaluronic Acid/Collagenase Ointment in the Treatment of Chronic Hard-to-Heal Wounds: An Observational and Retrospective Study. J. Clin. Med. 2022, 11, 537.

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