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TIMING AND REGENERATION FOR WOUND CARE THE EVOLUTION OF WOUND BED PREPARATION Unique formulation promoting a rapid wound healing process thanks to Hyaluronic Acid, assisted by the ancillary action of Collagenase. by the ancillary action of Collagenase. Boost healing since the beginning. Ancillary action of Collagenase on necrotic tissue in wound bed preparation(2). Very smooth and simple to apply(1,3). 3) . Hyaluronic Acid Sodium Salt 0.2% Collagenase from Vibrio alginolyticus Ointment | 30 g Tube for topical use Vascular Ulcer Case: RESULTS(4) Class III Medical Device 0373 No need to protect peri-wound skin(2). Less pain experienced by the patients(3). INDICATIONS Local management of chronic ulcers (i.e. pressure sores, vascular ulcers of the legs, diabetic ulcers). In particular, it is intended to provide an optimal moist environment and wound bed preparation that supports the natural healing process(1). REFERENCES: 1. HYALO4 CARE START, instruction for use; 2. Di Pasquale R, Vaccaro S, Caputo M, et al. Collagenase-assisted wound bed preparation: An in vitro comparison between Vibrio alginolyticus and Clostridium histolyticum collagenases on substrate specificity. Int Wound J. 2019;1–11; 3. Onesti MG, Fioramonti P, Fino P, Sorvillo V, Carella S, Scuderi N. Effect of enzymatic debridement with two different collagenases versus mechanical debridement on chronic hard-to- heal wounds. Int Wound J. 2016;13(6):1111-5; 4. De Francesco F, De Francesco M and Riccio M. Hyaluronic Acid/Collagenase Ointment in the Treatment of Chronic Hard-to-Heal Wounds: An Observational and Retrospective Study. J. Clin. Med. 2022, 11, 537. www.fidiapharma.com
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Editor Selma Maloumi selma.maloumi@markallengroup.com Chief Sub Editors Brian Cooper Lindsey Stewar t Consultant Editor Tracy Cowan Sales Director Emma Blick emma.blick@markallengroup.com Circulation Director Sally Boettcher sally.boettcher@markallengroup.com Production Manager Kyri Apostolou Production Assistant Charlotte Rutland Editorial Director Sophie Gardner Publishing Director Andrew Iafrati Managing Director Anthony Kerr anthony.kerr@markallengroup.com Chief Executive Officer Ben Allen JWC is available in many libraries and is indexed on several databases, including: • Science Citation Index Expanded and Current Contents/Clinical Medicine from Thomson Reuters • MEDLINE National Librar y of Medicine • CINAHL The Cumulative Index to Nursing and Allied Health Literature • RCN The Royal College of Nursing Librar y Nursing Bibliography • HINARI Access to Research in Health Programme, par t of the Research4Life initiative Cover picture: Bogota skyline at night. Copyright holder: Adobe Stock/antony This year’s cover theme is ‘Cities’. the monthly international wound-care journal Contents P P P P E P R JOURNAL OF WOUND CARE VOL 33, NO 2, FEBRUARY 2024 83 83 Editorial: Plastic, reconstructive and aesthetic surgery: a perspective  Editorial: Plastic, reconstructive and aesthetic surgery: a perspective  C Can Cedidi C Can Cedidi 84 84 A double-blind trial comparing an antimicrobial combination to standard care in A double-blind trial comparing an antimicrobial combination to standard care in hard-to-heal wounds  hard-to-heal wounds  Hard-to-heal wounds were evaluated, and target ulcers were Hard-to-heal wounds were evaluated, and target ulcers were randomised to be cleaned and treated with either a synergistic antibiofilm cleanser randomised to be cleaned and treated with either a synergistic antibiofilm cleanser and antibiofilm gel with standard of care or normal saline wash and an amorphous and antibiofilm gel with standard of care or normal saline wash and an amorphous gel with standard of care.  gel with standard of care.  Maha Khan, Emily King, Kristy Breisinger, Laura Serena, Maha Khan, Emily King, Kristy Breisinger, Laura Serena, Thomas E Serena Thomas E Serena 90 90 Remote assessment and monitoring with advanced wound therapy to optimise Remote assessment and monitoring with advanced wound therapy to optimise clinical outcomes, access and resources  clinical outcomes, access and resources  Patients with hard-to-heal wounds Patients with hard-to-heal wounds were enrolled in this 12-week pilot study to validate a shared care approach were enrolled in this 12-week pilot study to validate a shared care approach using an Advanced Digital Wound Care Platform-telehealth using an Advanced Digital Wound Care Platform-telehealth system coupled system coupled with continuous topical oxygen therapy.  with continuous topical oxygen therapy.  Aliza Lee, Emma Woodmansey, Aliza Lee, Emma Woodmansey, Benjamin Klopfenstein, Jessica L O’Leary, Windy Cole Benjamin Klopfenstein, Jessica L O’Leary, Windy Cole 102 102 Malignant wound aetiology, diagnosis and management: a case series and Malignant wound aetiology, diagnosis and management: a case series and literature review  literature review  This case series examined 11 patients with malignant wounds This case series examined 11 patients with malignant wounds of varying aetiology and appearance. For each case, the pathophysiology, atypical of varying aetiology and appearance. For each case, the pathophysiology, atypical features, diagnostic approach and treatment are explained. features, diagnostic approach and treatment are explained.  Lauren Fang,   Lauren Fang, Richard Simman, Lauren Workman, Samar Ayoub, Camille Bratton Richard Simman, Lauren Workman, Samar Ayoub, Camille Bratton 118 118 Treatment of clinically uninfected diabetic foot ulcers, with and without antibiotics  Treatment of clinically uninfected diabetic foot ulcers, with and without antibiotics  In this retrospective study of 91 consecutive patients with a total of 102 ulcers, In this retrospective study of 91 consecutive patients with a total of 102 ulcers, primary outcome was ulcer healing at one year. Secondary outcomes were limb primary outcome was ulcer healing at one year. Secondary outcomes were limb salvage, freedom from any amputation, amputation-free survival and survival.  salvage, freedom from any amputation, amputation-free survival and survival.  Eline Huizing, Michiel A Schreve, James WT Cohen Stuart, Jean-Paul PM de Vries, Eline Huizing, Michiel A Schreve, James WT Cohen Stuart, Jean-Paul PM de Vries, ÇaÇağdadaş Ünlü Ünlü 127 127 Scalp wound management: a narrative review from a neurosurgical perspective  Scalp wound management: a narrative review from a neurosurgical perspective  In this review, PubMed was searched for publications and book chapters, as well as In this review, PubMed was searched for publications and book chapters, as well as commonly referenced papers considered relevant to the subject. Relevant reference commonly referenced papers considered relevant to the subject. Relevant reference lists of publications identified by the search were also searched and relevant papers lists of publications identified by the search were also searched and relevant papers included.included.  Santiago Cardona, Carolina Hernández, Maria Paz Bohórquez-Tarazona,   Santiago Cardona, Carolina Hernández, Maria Paz Bohórquez-Tarazona, Andrés M Rubiano, Diana Marcela Sánchez Parra Andrés M Rubiano, Diana Marcela Sánchez Parra 136 136 Impact of haemoglobin A1c on wound infection in patients with diabetes with Impact of haemoglobin A1c on wound infection in patients with diabetes with implanted synthetic graft implanted synthetic graft  Patients with type 2 diabetes were divided into two   Patients with type 2 diabetes were divided into two groups according to preoperative HbA1c values. The association between groups according to preoperative HbA1c values. The association between preoperative long‑term glycoregulation and wound infection, and the impact of preoperative long‑term glycoregulation and wound infection, and the impact of postoperative glycaemic values were evaluated. postoperative glycaemic values were evaluated.  Predrag Mati   Predrag Matić, Igor Atanasijevi , Igor Atanasijević, , Vera Maravi Vera Maravić Stojkovi Stojković, Ivan Soldatovi , Ivan Soldatović, Slobodan Tanaskovi , Slobodan Tanasković, Sr , Srđan Babi an Babić, , Predrag Gajin, Branko Lozuk, Goran Vu Predrag Gajin, Branko Lozuk, Goran Vučureviurević, Aleksandra Đokovi , Aleksandra Đoković, Rastko Živi , Rastko Živić, , Vuk Đuleji Vuk Đulejić, Mihailo Neškovi , Mihailo Nešković, Aleksandar Babi , Aleksandar Babić, Nenad Ilijevski , Nenad Ilijevski 143 143 Pressure injury risk factors in adult orthopaedic surgical patients: a cross‑ Pressure injury risk factors in adult orthopaedic surgical patients: a cross‑ sectional study and random forest sectional study and random forest  Patients were assessed with an instrument   Patients were assessed with an instrument designed by the authors specifically for this study. The random forest method designed by the authors specifically for this study. The random forest method was adopted to select the most important risk factors and predict occurrence of was adopted to select the most important risk factors and predict occurrence of pressure injuries.  pressure injuries.  Dan Zhao, Jiao Jin, Qiong Luo, Zhiwen Wang, Jinbing An Dan Zhao, Jiao Jin, Qiong Luo, Zhiwen Wang, Jinbing An S1– S40 S1– S40 WUWHS Supplement  WUWHS Supplement  This edition features a study of the effect of prophylactic This edition features a study of the effect of prophylactic dressings in reducing pressure injuries using a polymer‑based skin model; a dressings in reducing pressure injuries using a polymer‑based skin model; a description of the ability of sprayable hydroxypropyl chitin/collagen extract description of the ability of sprayable hydroxypropyl chitin/collagen extract of of Ampelopsis brevipedunculata Ampelopsis brevipedunculata hydrogel to accelerate wound healing; a case hydrogel to accelerate wound healing; a case series investigating the role of medical-grade maggots in facilitating healing of series investigating the role of medical-grade maggots in facilitating healing of diabetic foot ulcers; and a study of nutritional factors and pressure injury risk in diabetic foot ulcers; and a study of nutritional factors and pressure injury risk in hospitalised patients post-stroke. hospitalised patients post-stroke. Research supplement – online only: Research supplement – online only: x x The therapeutic effect of concentrated growth factor gel on skin wounds with The therapeutic effect of concentrated growth factor gel on skin wounds with bone or tendon exposure  bone or tendon exposure  Binxiong Chen, Changneng Ke, Songyun Zou, Yang Liu, Binxiong Chen, Changneng Ke, Songyun Zou, Yang Liu, Dengshan Chen, Yueming Liu, Shi Xu Dengshan Chen, Yueming Liu, Shi Xu xiv xiv The healing effect of a mixture of The healing effect of a mixture of Arnebia euchroma Arnebia euchroma and animal fat on burn and animal fat on burn wounds in rats in comparison with sulfadiazine  wounds in rats in comparison with sulfadiazine  Saied Habibian Dehkordi, Saied Habibian Dehkordi, Iraj Karimi, Paul Mills, Sadegh Shirian Iraj Karimi, Paul Mills, Sadegh Shirian x x x x Polyurethane foam dressing with non-adherent membrane improves negative Polyurethane foam dressing with non-adherent membrane improves negative pressure wound therapy in pigs  pressure wound therapy in pigs  Jun Zuo, Yi Zhu, Yong Yang, JunTao Yang, Jun Zuo, Yi Zhu, Yong Yang, JunTao Yang, Ze Lin Huang, Biao Cheng Ze Lin Huang, Biao Cheng xxviii xxviii Complex decongestive therapy in hidradenitis suppurativa-related genital Complex decongestive therapy in hidradenitis suppurativa-related genital lymphoedema: a case report  lymphoedema: a case report  AyAyşegül Yaman, Pınar Borman, Pelin E egül Yaman, Pınar Borman, Pelin Eşme, me, Ercan Çalı Ercan Çalışkankan xxxii xxxii Comparison of different concentrations of chlorhexidine-iodophor composite Comparison of different concentrations of chlorhexidine-iodophor composite solution on human skin fibroblasts  solution on human skin fibroblasts  Luo YiXin, Niu ShaoNa, Mai LiFang, Luo YiXin, Niu ShaoNa, Mai LiFang, Liu XingZhou, Yang Chuan Liu XingZhou, Yang Chuan xli xli Evaluation of a new low-cost negative pressure wound therapy in the Evaluation of a new low-cost negative pressure wound therapy in the treatment of diabetic foot ulcers treatment of diabetic foot ulcers  Haojie Sun, Shanwen Si, Xuekui Liu, Houfa Geng,   Haojie Sun, Shanwen Si, Xuekui Liu, Houfa Geng, Jun Liang Jun Liang P  ractice E  ducation R  esearch M  anagement C  omment 81

TIMING AND REGENERATION FOR WOUND CARE

THE EVOLUTION OF WOUND BED PREPARATION Unique formulation promoting a rapid wound healing process thanks to Hyaluronic Acid, assisted by the ancillary action of Collagenase.

by the ancillary action of Collagenase.

Boost healing since the beginning.

Ancillary action of Collagenase on necrotic tissue in wound bed preparation(2).

Very smooth and simple to apply(1,3).

3) .

Hyaluronic Acid Sodium Salt 0.2% Collagenase from Vibrio alginolyticus Ointment | 30 g Tube for topical use

Vascular Ulcer Case: RESULTS(4)

Class III Medical Device

0373

No need to protect peri-wound skin(2).

Less pain experienced by the patients(3).

INDICATIONS

Local management of chronic ulcers (i.e. pressure sores, vascular ulcers of the legs, diabetic ulcers).

In particular, it is intended to provide an optimal moist environment and wound bed preparation that supports the natural healing process(1).

REFERENCES: 1. HYALO4 CARE START, instruction for use; 2. Di Pasquale R, Vaccaro S, Caputo M, et al. Collagenase-assisted wound bed preparation: An in vitro comparison between Vibrio alginolyticus and Clostridium histolyticum collagenases on substrate specificity. Int Wound J. 2019;1–11; 3. Onesti MG, Fioramonti P, Fino P, Sorvillo V, Carella S, Scuderi N. Effect of enzymatic debridement with two different collagenases versus mechanical debridement on chronic hard-to- heal wounds. Int Wound J. 2016;13(6):1111-5; 4. De Francesco F, De Francesco M and Riccio M. Hyaluronic Acid/Collagenase Ointment in the Treatment of Chronic Hard-to-Heal Wounds: An Observational and Retrospective Study. J. Clin. Med. 2022, 11, 537.

www.fidiapharma.com

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